HIV-1 gp120

By Targets:	HIV (14)
By Research Areas:	Infection (13) Inflammation/Immunology (3)

Targets Recommended: HIV HIV Integrase HIV Protease

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-76648

NBD-556	HIV	Infection
NBD-556, a CD4 mimetic, is a potent *HIV-1* entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels ^[1] .

HY-139985

NBD-14189	HIV	Infection
NBD-14189 is a potent *HIV-1* entry antagonist with an IC₅₀ of 89 nM against the HIV-1_HXB2 pseudovirus. NBD-14189 binds to HIV-1 gp120 and shows potent antiviral activity (EC₅₀<200 nM) ^[1] .

HY-P4055

GP120, HIV-1 MN

HIV Infection Inflammation/Immunology

GP120, HIV-1 MN is a peptide. GP120, HIV-1 MN can be used for the research of HIV infection ^[1] .

GP120, HIV-1 MN	HIV	Infection Inflammation/Immunology
GP120, HIV-1 MN is a peptide. GP120, HIV-1 MN can be used for the research of HIV infection ^[1] .

HY-144730

gp120-IN-1	HIV	Inflammation/Immunology
gp120-IN-1 (compound 4e) is a potent **HIV-1 gp120 inhibitor with an IC₅₀ of 2.2 µM and CC₅₀** of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells ^[1].

HY-144731

gp120-IN-2	HIV	Inflammation/Immunology
gp120-IN-2 (compound 4i) is a potent **HIV-1 gp120 inhibitor with an IC₅₀ of 7.5 µM and CC₅₀** of 112.93 µM. gp120-IN-2 shows anti-HIV-1 activity. gp120-IN-2 shows cytotoxicity in a dose dependent manner in SUP-T1 cells ^[1].

HY-139989

NBD-14270	HIV	Infection
NBD-14270, a pyridine analogue, is a potent *HIV-1* entry antagonist with an IC₅₀ of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC₅₀>100 μM) ^[1] .

HY-14134

BMS-378806 5 Publications Verification BMS-806	HIV	Infection
BMS-378806 is a potent *HIV-1* attachment inhibitor that interferes with CD4-gp120 interactions. BMS-378806 selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC₅₀ of 0.85-26.5 nM in virus.

HY-P99102

Zinlirvimab

10-1074
HIV Infection

Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, *HIV* neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

HY-P3554

Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl	HIV	Infection
Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (compound (CPF(LL)) is an *HIV-1* inhibitor. Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl interacts with *gp120* to block *gp120* binding to CD4 and preserve CD4-dependent T cell function ^[1].

HY-15440

Temsavir 4 Publications Verification BMS-626529	HIV	Infection
Temsavir (BMS-626529) is a novel attachment inhibitor that targets *HIV-1* gp120 and prevents its binding to CD4 ⁺ T cells.

HY-P0272

Peptide T

HIV Infection

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

Peptide T	HIV	Infection
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of *HIV* to the CD4 receptor.

HY-P0272A

Peptide T TFA	HIV	Infection
Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of *HIV* to the CD4 receptor.

HY-15440A

Fostemsavir BMS-663068	HIV	Infection
Fostemsavir (BMS-663068) is the phosphonooxymethyl prodrug of BMS-626529. Fostemsavir (BMS-663068) is a novel attachment inhibitor that targets *HIV-1* gp120 and prevents its binding to CD4 ⁺ T cells.

HY-15440B

Fostemsavir Tris BMS-663068 Tris	HIV	Infection
Fostemsavir Tris (BMS-663068 (Tris)) is the phosphonooxymethyl proagent of BMS-626529. Fostemsavir Tris (BMS-663068 (Tris)) is a novel attachment inhibitor that targets *HIV-1* gp120 and prevents its binding to CD4 ⁺ T cells.

Cat. No.	Product Name	Target	Research Area

HY-P0272

Peptide T

HIV Infection

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
HY-P4055

GP120, HIV-1 MN

HIV Infection Inflammation/Immunology

GP120, HIV-1 MN is a peptide. GP120, HIV-1 MN can be used for the research of HIV infection ^[1] .

Peptide T	HIV	Infection
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of *HIV* to the CD4 receptor.

GP120, HIV-1 MN	HIV	Infection Inflammation/Immunology
GP120, HIV-1 MN is a peptide. GP120, HIV-1 MN can be used for the research of HIV infection ^[1] .

HY-P3554

Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl	HIV	Infection
Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl (compound (CPF(LL)) is an *HIV-1* inhibitor. Carbomethoxycarbonyl-D-Pro-D-Phe-OBzl interacts with *gp120* to block *gp120* binding to CD4 and preserve CD4-dependent T cell function ^[1].

HY-P0272A

Peptide T TFA	HIV	Infection
Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of *HIV* to the CD4 receptor.

HY-P4902

Retrocyclin-1	Peptides	Infection
Retrocyclin-1 is a kind of Theta-defensin. Retrocyclin-1 recognizes and binds to carbohydrate-containing surface molecules, to protect cells from *HIV-1* infection. Retrocyclin-1 exhibits high affinity to fetuin, gp120 (K_d=35.4 nM), CD4 (K_d=31 nM), and galactosylceramide (K_d=24.1 nM) ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99102

Zinlirvimab

10-1074
HIV Infection

Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, *HIV* neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

Recombinant Proteins Recommended:

HIV-1 gp120

Species:	Virus (7)
Tag:	His (7)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P76390

	*envelope glycoprotein gp120* Protein, HIV-1 (AAC31819, HEK293, His)** Human immunodeficiency virus 1 (HIV-1) (group M, subtype B, Isolate MN) gp120 Protein (His)	Virus	HEK293
	The envelope glycoprotein gp120 protein facilitates viral capture and dissemination by dendritic cells and endothelial cells by attaching the virus to host lymphocytes through binding to the CD4 receptor. HIV exploits the migratory properties of dendritic cells to access CD4+ T cells, leading to infection. envelope glycoprotein gp120 Protein, HIV-1 (AAC31819, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, HIV-1 (AAC31819, HEK293, His) is 484 a.a., with molecular weight of 95-130 kDa.

HY-P74120

	*envelope glycoprotein gp120* Protein, HIV-1 (AAC57427, HEK293 , His)** Envelope glycoprotein gp160; Env polyprotein; gp120; gp41; env	Virus	HEK293
	envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, HIV-1 (AAC57427, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, HIV-1 (AAC57427, HEK293, His) is 479 a.a., with molecular weight of ~55.4 kDa.

HY-P74121

	*envelope glycoprotein gp120* Protein, HIV-1 (AAA44191, HEK293 , His)** Envelope glycoprotein gp160; Env polyprotein; gp120; gp41; env	Virus	HEK293
	envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, HIV-1 (AAA44191, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of envelope glycoprotein gp120 Protein, HIV-1 (AAA44191, HEK293, His) is 480 a.a., with molecular weight of 95-150 kDa.

HY-P74118

	*envelope glycoprotein gp120* Protein, HIV-1 (ACY40659, HEK293, His)** Envelope glycoprotein gp160; Env polyprotein; gp120; gp41; env	Virus	HEK293
	envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, HIV-1 (ACY40659, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, HIV-1 (ACY40659, HEK293, His) is 490 a.a., with molecular weight of ~56.2 kDa.

HY-P74119

	*envelope glycoprotein gp120* Protein, HIV-1 (AFM77980, HEK293, His)** Envelope glycoprotein gp160; Env polyprotein; gp120; gp41; env	Virus	HEK293
	envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, HIV-1 (AFM77980, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, HIV-1 (AFM77980, HEK293, His) is 474 a.a., with molecular weight of 70-120 kDa.

HY-P76383

	envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) HIV-1 gp160 Protein (gp120 subunit) (group N, strain 06CM-U14296)	Virus	HEK293
	Envelope glycoprotein gp160 Protein (HIV-1 gp160 Protein) is the sole antigenic protein on the surface of the HIV-1 virion and mediates HIV-1 entry into target cells. The endoproteolytic processing of HIV-1 gp160 membrane glycoprotein precursor into gp120 and gp41 is necessary for formation of infectious HIV particles. HIV-1 gp160 induces endothelial cell apoptosis, which is mediated by CXCR4 chemokine receptor. envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp160 Protein, HIV-1 (ADD25380, HEK293, His) is 473 a.a., with molecular weight of ~54.4 KDa.

HY-P74885

	envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) HIV-1 (group M, subtype A, isolate 92RW020) Envelope glycoprotein gp160 Protein (gp120 subunit) (His)	Virus	HEK293
	gp160 is an envelope glycoprotein that oligomerizes into major trimers in the host endoplasmic reticulum. gp160 is transported in the host Golgi apparatus to complete the glycosylation process. The precursors are proteolytic cleaved in the trans-Golgi apparatus to produce gp120 and gp41. envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp160 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp160 Protein, HIV-1 (AAT67478, HEK293, His) is 464 a.a., with molecular weight of ~52.2 kDa.


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